Indazole-4-boronic acid p...

Indazole-4-boronic acid p... - Names and Identifiers

Name	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
Synonyms	Indazole-4-boronic acid p... 2-dioxaborolan-2-yl)-1H-indazole 1H-indazol-4-boronic acid pinacol ester 1H-Indazole-4-boronic acid pinacol ester 1H-Indazol-4-ylboronic acid pinacol ester 1H-Indazol-4-ylboronic Acid Pinacol Ester 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indazole 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole 1H-Indazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 1H-indazol-4-ylboronate
CAS	885618-33-7
InChI	InChI=1/C13H17BN2O2/c1-12(2)13(3,4)18-14(17-12)10-6-5-7-11-9(10)8-15-16-11/h5-8H,1-4H3,(H,15,16)

Indazole-4-boronic acid p... - Physico-chemical Properties

Molecular Formula	C13H17BN2O2
Molar Mass	244.1
Density	1.154g/cm³
Melting Point	139-142℃
Boling Point	404.123°C at 760 mmHg
Flash Point	198.207°C
Vapor Presure	0mmHg at 25°C
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.564
MDL	MFCD08059267

Indazole-4-boronic acid p... - Introduction

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole) is an organic compound with the chemical formula C14H18BNO2.

Nature:
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is a colorless crystalline solid that can be dissolved in some organic solvents, such as dimethyl sulfoxide (DMSO), chloroform and dichloromethane.

Use:
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is commonly used as a reagent in organic synthesis and can be used to synthesize other organic compounds. It also has potential application value in drug research.

Preparation Method:
Preparation of 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is typically obtained by reaction of 1H-indazole-4-boronic acid with 4-bromo-1H-indazole. First, 1H-indazole-4-boronic acid and sodium carbonate are added to a reaction solvent (e. g., dimethyl sulfoxide), and an alkali metal bromide (e. g., potassium bromide) and an activator (e. g., iodide) are added at low temperature to obtain a product after a period of reaction. Finally, the target compound is obtained in higher purity by appropriate purification steps such as crystallization separation, washing and drying.

Safety Information:
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is relatively safe under normal conditions of use. However, as a chemical, it still requires proper handling and storage. When in use, you should comply with relevant safety operating requirements, wear appropriate personal protective equipment, avoid direct contact with skin and eyes, and ensure that you operate in a well-ventilated place. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 21:01:54